超强静磁场对小鼠抗氧化和免疫功能的影响

上海大学学报(自然科学版) ›› 2009, Vol. 15 ›› Issue (2): 211-215.

超强静磁场对小鼠抗氧化和免疫功能的影响

张璐，王沂，胡俊，翁新楚

（上海大学生命科学学院，上海 200444）

收稿日期:2007-11-01 出版日期:2009-04-22 发布日期:2009-04-21
通讯作者: 翁新楚(1962～)，男，教授，博士生导师，研究方向为天然产物化疗. E-mail:wxch@staff.shu.edu.cn
作者简介:翁新楚(1962～)，男，教授，博士生导师，研究方向为天然产物化疗. Email:wxch@staff.shu.edu.cn

Effects of Ultra High Static Magnetic Fields on Antioxidation -and Immune Function of Mice

ZHANG Lu,WANG Yi,HU Jun,WENG Xinchu

(School of Life Sciences, Shanghai University, Shanghai 200444, China)

Received:2007-11-01 Online:2009-04-22 Published:2009-04-21

摘要/Abstract

摘要：

研究超强静磁场对一周龄小鼠抗氧化和免疫功能的影响.采用磁感应强度为12 T的超强静磁场分别照射小鼠8，12，16 h，照射结束后6，12，24 h，分别取肝脏检测过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）的活力和丙二醛（MDA）含量,取胸腺和脾脏，测定胸腺、脾脏指数和脾淋巴细胞增殖率.结果表明，超强静磁场可以显著提高小鼠肝脏的CAT和GSH-Px的活力，降低MDA含量，提高机体处理自由基的能力，减少脂质过氧化产物的生成；磁场显著提高小鼠的脾淋巴细胞增殖率，脾脏和胸腺指数也有所升高.试验表明，超强静磁场可以提高机体的抗氧化能力和免疫功能，从而增强机体抗病能力，对延缓衰老有积极作用.

关键词: 超强静磁场；抗氧化；脾淋巴细胞

Abstract:

This study is focused on the antioxidation and immune effect of the strong static magnetic fields on mice. Mice were exposed to ultra static magnetic fields at 12 T for 8, 12, 16 hours respectively. After exposure for 6, 12, 24 hours, their livers were taken to measure the activities of CAT, GSH-Px and content of MDA. Their thymus and spleens were used to measure the index of thymus and spleens and the proliferation of splenic lymphocyte. The results showed that activities of CAT and GSH-Px were increased significantly, but the MDA content was decreased. These phenomena indicated enhancement of antioxidation ability and reduction of the production of lipid peroxidation. Furthermore, proliferation of splenic lymphocyte was increased remarkably and indexes of thymus and spleens were also increased. The results showed that the strong static magnetic fields can improve antioxidation and immune function of the body, thus enhanced the ability to resist diseases and delay aging process.

Key words: ultra high static magnetic field; antioxidation function; splenic lymphocyte

中图分类号:

Q 64

张璐王沂胡俊翁新楚. 超强静磁场对小鼠抗氧化和免疫功能的影响[J]. 上海大学学报(自然科学版), 2009, 15(2): 211-215.

ZHANG Lu, WANG Yi, HU Jun, WENG Xin-Chu. Effects of Ultra High Static Magnetic Fields on Antioxidation -and Immune Function of Mice[J]. Journal of Shanghai University（Natural Science Edition）, 2009, 15(2): 211-215.