广西龙血竭游离黄酮类化合物的分离鉴定及活性研究

上海大学学报(自然科学版)

广西龙血竭游离黄酮类化合物的分离鉴定及活性研究

周晓惠1，吕敬慈1，雍克岚2

1.上海大学理学院，上海 200444； 2.上海大学生命科学学院，上海 200444

收稿日期:2006-04-25 修回日期:1900-01-01 出版日期:2007-04-30 发布日期:2007-04-30
通讯作者: 吕敬慈

Separation, Identification and Activity of Free Flavonoids in Resina Draconis

ZHOU Xiao-hui1，LU Jing-ci1，YONG Ke-lan2

1. School of Sciences, Shanghai University, Shanghai 200444, China; 2. School of Life Sciences, Shanghai University, Shanghai 200444, China

Received:2006-04-25 Revised:1900-01-01 Online:2007-04-30 Published:2007-04-30
Contact: LU Jing-ci

摘要/Abstract

摘要： 根据血竭中游离黄酮存在着酸性差异，采用溶剂除杂，转溶于乙醚，再用pH梯度萃取得到不同酸性的黄酮，进而对弱酸性组分分离纯化得到2个单体化合物.通过考察不同提取部位对α-D-葡萄糖苷酶抑制活性的变化，发现弱酸性成分的活性较强，比血竭全粉提高45.5%，为研究龙血竭中黄酮类化合物对α-D-葡萄糖苷酶的抑制作用提供依据.

关键词: α-D-葡萄糖苷酶, 龙血竭, 游离黄酮

Abstract: According to different acidity of free Flavonoids in Resina Draconis, different acidic lavonoids were extracted with the pH gradient extraction method from ethyl ether. Two compounds were isolated from weak acidicmixture. Weak acidic compounds showed higher activity in comparing to the crude powder of Guangxi Resina Draconis with 45.5% increase of IC₅₀. This provides a useful reference to the study of inhibitive activity of flavones for α-D-glucosidase enzyme.

Key words: free Flavonoids, α-D-glucosidase enzyme, Resina Draconis

中图分类号:

O 629.2

周晓惠;吕敬慈;雍克岚. 广西龙血竭游离黄酮类化合物的分离鉴定及活性研究[J]. 上海大学学报(自然科学版).

ZHOU Xiao-hui;LU Jing-ci;YONG Ke-lan. Separation, Identification and Activity of Free Flavonoids in Resina Draconis
[J]. Journal of Shanghai University（Natural Science Edition）.