模板法制备银纳米点阵活性基底及其用于葡萄糖的高灵敏检测

doi:10.3969/j.issn.1007-2861.2014.03.004

上海大学学报(自然科学版) ›› 2015, Vol. 21 ›› Issue (1): 54-63.doi: 10.3969/j.issn.1007-2861.2014.03.004

模板法制备银纳米点阵活性基底及其用于葡萄糖的高灵敏检测

郭合帅1, 付群1, 林伟1, 郑贤正1, 鲁波2, 吴明红1, 雷勇1

1. 上海大学环境与化学工程学院, 上海 200444; 2. 上海大学分析测试中心, 上海 200444

收稿日期:2014-03-05 出版日期:2015-02-28 发布日期:2015-02-28
通讯作者: 吴明红(1968—), 女, 教授, 博士生导师, 博士, 研究方向为辐射化学和纳米器件. E-mail:mhwu@staff.shu.edu.cn
基金资助:
国家杰出青年科学基金资助项目(11025526); 国家自然科学基金资助项目(41073073, 51301104); 长江学者和创新团队发展计划资助项目(IRT13078); 上海市科委科技专项资助项目(13230500600); 上海市千人计划资助项目; 上海市东方学者资助项目

Template preparation of Ag nanoparticle arrays SERS-active substrate and highly sensitive detection of glucose

GUO He-shuai1, FU Qun1, LIN Wei1, ZHENG Xian-zheng1, LU Bo2, WU Ming-hong1, LEI Yong1

1. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China; 2. Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China

Received:2014-03-05 Online:2015-02-28 Published:2015-02-28

摘要/Abstract

摘要： 介绍了基于超薄氧化铝模板(ultra-thin alumina mask, UTAM)制备的金属银纳米点阵表面增强拉曼散射(surface-enhanced Raman scattering, SERS)活性基底用于葡萄糖的高灵敏检测方法. 以UTAM为模板, 采用真空镀膜制备了大面积高度有序的银纳米点阵活性基底. 该基底的表面经过预处理, 吸附了一层癸硫醇/巯基己醇自组装分子层, 可用于检测葡萄糖. 研究结果表明, 该基底使葡萄糖分子的表面拉曼增强信号得到极大增强, 且增强信号均一稳定、检测灵敏, 特征峰的强度相对标准偏差小于10%. 该制备方法具有易操作、成本低的特点.

关键词: 表面增强拉曼散射, 超薄氧化铝模板, 纳米点阵, 葡萄糖, 生理浓度

Abstract: A highly sensitive method for detecting glucose using Ag nanoparticle arrays surface-enhanced Raman scattering (SERS) active substrates based on the ultra-thin alumina mask (UTAM) was reported. The large-area highly ordered Ag nanoparticle arrays active substrates were fabricated using thermal evaporation with UTAM as a shadow mask in vacuum. The surface of active substrates can adsorb a layer of decanethiol/mercaptohexanol (DT/MH) self-assembled monolayers (SAM) through the surface pretreatment. Therefore the active substrates can be used for detecting glucose molecules. SERS measurement results of the active substrate with glucose molecules as probe molecules show strong SERS performance, and the enhanced signal is uniform and stable. The relative standard deviation (RSD) of the characteristic peak intensity is less than 10%. This preparation method has the advantages of simple operation and low cost.

Key words: glucose, nanoparticle, physiological concentration, surface-enhanced Raman scattering (SERS), ultra-thin alumina mask (UTAM)

中图分类号:

TU 411

郭合帅1, 付群1, 林伟1, 郑贤正1, 鲁波2, 吴明红1, 雷勇1. 模板法制备银纳米点阵活性基底及其用于葡萄糖的高灵敏检测[J]. 上海大学学报(自然科学版), 2015, 21(1): 54-63.

GUO He-shuai1, FU Qun1, LIN Wei1, ZHENG Xian-zheng1, LU Bo2, WU Ming-hong1, LEI Yong1. Template preparation of Ag nanoparticle arrays SERS-active substrate and highly sensitive detection of glucose[J]. Journal of Shanghai University（Natural Science Edition）, 2015, 21(1): 54-63.

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模板法制备银纳米点阵活性基底及其用于葡萄糖的高灵敏检测

Template preparation of Ag nanoparticle arrays SERS-active substrate and highly sensitive detection of glucose

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