灵芝黄芪复配物提高环磷酰胺对荷瘤小鼠的疗效

doi:10.3969/j.issn.1007-2861.2012.04.018

上海大学学报(自然科学版) ›› 2012, Vol. 18 ›› Issue (4): 425-429.doi: 10.3969/j.issn.1007-2861.2012.04.018

灵芝黄芪复配物提高环磷酰胺对荷瘤小鼠的疗效

张佳俊，廖鲜艳，翁新楚

（上海大学生命科学学院，上海 200444）

出版日期:2012-08-30 发布日期:2012-08-30
通讯作者: 翁新楚（1962~），男，教授，博士生导师，研究方向为天然产物的开发及利用等. E-mail:wxch@staff.shu.edu.cn

Efficacy of Compound of Ganoderma lucidum and AstragalusExtracts on TumorBearing Mice Treated by Cyclophosphamide

ZHANG Jia-jun,LIAO Xian-yan,WENG Xin-chu

(School of Life Sciences, Shanghai University, Shanghai 200444, China)

Online:2012-08-30 Published:2012-08-30

摘要/Abstract

摘要： 研究灵芝(Ganoderma lucidum)黄芪(Astragalus)复配物对环磷酰胺(cyclophosphamide,CTX)治疗的荷瘤小鼠肿瘤和免疫功能的影响.建立小鼠S180肉瘤模型，每日灌胃低、中、高剂量的灵芝黄芪复配物，并配合腹腔注射CTX.连续处理小鼠2周后，分析抑瘤效应，测定小鼠脾指数、胸腺指数、外周血白细胞(white blood cell,WBC)数和红细胞(red blood cell,RBC)数等免疫指标.同单CTX治疗组相比，中、高剂量的灵芝黄芪复配物能显著加强CTX对小鼠S180肉瘤的抑制作用（P<0.01），明显改善CTX引起的小鼠胸腺萎缩（P<0.01）和白细胞减少症状（P<0.05，P<0.01）.灵芝黄芪复配物对CTX的抑瘤治疗具有明显的增效减毒作用，其效果堪比于单味中药灵芝提取物辅助CTX的抑瘤疗效，可大大降低单味灵芝提取物的治疗成本，经济价值可观.

关键词: 黄芪, 抗肿瘤, 灵芝, 免疫功能

Abstract: Effects of the compound of Ganoderma lucidum and Astragalus extracts on immunity and tumor of mice treated by cyclophosphamide (CTX) were investigated. The mice were given both compounds of Ganoderma lucidum and Astragalus extracts by gavage and CTX by peritoneal injection for two weeks after the mouse model bearing S180 tumor were produced. Then the antitumor effect, the thymus index, spleen index and the amount of white blood cells (WBCs) and red blood cells (RBCs) were observed and determined. Compared with the CTX group, the middle and high dose group of Ganoderma lucidum and Astragalus extracts significantly enhanced the effect of CTX on inhibiting the growth of S180 tumor (P<0.01), and prominently relieve thymic atrophy (P<0.01) and leucopenia (P<0.05, P<0.01) caused by CTX in mice. The compound of Ganoderma lucidum and Astragalus extracts showed synergy and attenuation of CTX in tumor therapy. Its efficacy was equivalent to that of single folium Ganoderma lucidum extract, which largely reduced the cost of single folium Ganoderma lucidum extract with a great economical value.

Key words: Astragalus, Ganoderma lucidum, antitumor, immunity

中图分类号:

R 285.5

张佳俊，廖鲜艳，翁新楚. 灵芝黄芪复配物提高环磷酰胺对荷瘤小鼠的疗效[J]. 上海大学学报(自然科学版), 2012, 18(4): 425-429.

ZHANG Jia-jun,LIAO Xian-yan,WENG Xin-chu. Efficacy of Compound of Ganoderma lucidum and AstragalusExtracts on TumorBearing Mice Treated by Cyclophosphamide[J]. Journal of Shanghai University（Natural Science Edition）, 2012, 18(4): 425-429.

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灵芝黄芪复配物提高环磷酰胺对荷瘤小鼠的疗效

Efficacy of Compound of Ganoderma lucidum and AstragalusExtracts on TumorBearing Mice Treated by Cyclophosphamide

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