中文

Journal of Shanghai University >

2019 , Vol. 25 >Issue 3: 381 - 388

DOI: https://doi.org/10.12066/j.issn.1007-2861.2138

Epigenetic regulation in vascular aging

Expand
  • State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

Received date: 2019-04-22

  Online published: 2019-06-24

Fold

Abstract

Vascular aging refers to the structural and functional changes of aorta during the aging process. It is characterized by vascular remodeling, vascular dyshomeostasis and vascular cell senescence. Epigenetic regulation can influence gene expression without changing the DNA sequence and it mainly includes DNA methylation, histone modifications, and RNA-based gene regulation. Current researches demonstrate that epigenetic regulation plays important roles in vascular aging and age-related diseases, and drugs targeting epigenetic regulation are expected to be new treatments for age-related diseases.

Key words： vascular aging; epigenetic regulation; DNA methylation; histone modification; non-coding RNAs; Senescaging

Cite this article

DING Yangnan , LÜ Shuangjie , CHEN Houzao , LIU Depei . Epigenetic regulation in vascular aging[J]. Journal of Shanghai University, 2019 , 25(3) : 381 -388 . DOI: 10.12066/j.issn.1007-2861.2138

References

[1] Corella D, Ordovas J M . Aging and cardiovascular diseases: the role of gene-diet interactions[J]. Ageing Res Rev, 2014,18:53-73.
[2] Mathers C D, Loncar D . Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med, 2006,3(11):e442.
[3] Van Camp G . Cardiovascular disease prevention[J]. Acta Clin Belg, 2014,69(6):407-411.
[4] Ding Y N, Tang X, Chen H Z , et al. Epigenetic regulation of vascular aging and age-related vascular diseases[J]. Adv Exp Med Biol, 2018,1086:55-75.
[5] Feinberg A P . The key role of epigenetics in human disease prevention and mitigation[J]. N Engl J Med, 2018,378(14):1323-1334.
[6] Sen P, Shah P P, Nativio R , et al. Epigenetic mechanisms of longevity and aging[J]. Cell, 2016,166(4):822-839.
[7] Jeltsch A . Reading and writing DNA methylation[J]. Nat Struct Mol Biol, 2008,15(10):1003-1004.
[8] Tsaprouni L G, Yang T P, Bell J , et al. Cigarette smoking reduces DNAmethylation levels at multiple genomic loci but the effect is partially reversible upon cessation[J]. Epigenetics, 2014,9(10):1382-1396.
[9] Hai Z, Zuo W . Aberrant DNA methylation in the pathogenesis of atherosclerosis[J]. Clin Chim Acta, 2016,456:69-74.
[10] Cutolo M, Paolino S, Pizzorni C . Possible contribution of chronic inflammation in the induction of cancer in rheumatic diseases[J]. Clin Exp Rheumatol, 2014,32(6):839-847.
[11] Liu X L, Zhang P F, Ding S F , et al. Local gene silencing of monocyte chemoattractant protein-1 prevents vulnerable plaque disruption in apolipoprotein E-knockout mice[J]. PLoS One, 2012,7(3):e33497.
[12] Chan Y, Fish J E, D'Abreo C, et al. The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation[J]. J Biol Chem, 2004,279(33):35087-35100.
[13] Cencioni C, Spallotta F, Martelli F , et al. Oxidative stress and epigenetic regulation in ageing and age-related diseases[J]. Int J Mol Sci, 2013,14(9):17643-17663.
[14] Ventura A, Luzi L, Pacini S , et al. The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter[J]. J Biol Chem, 2002,277(25):22370-22376.
[15] Toghill B J, Saratzis A, Harrison S C , et al. The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm[J]. Atherosclerosis, 2015,241(1):121-129.
[16] Calvanese V, Lara E, Kahn A , et al. The role of epigenetics in aging and age-related diseases[J]. Ageing Res Rev, 2009,8(4):268-276.
[17] Wan Y Z, Gao P, Zhou S , et al. SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence[J]. Aging Cell, 2014,13(5):890-899.
[18] Gracia-Sancho J, Villarreal G, Zhang Y, Jr , et al. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype[J]. Cardiovasc Res, 2010,85(3):514-519.
[19] Chen H Z, Wang F, Gao P , et al. Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm[J]. Circ Res, 2016,119(10):1076-1088.
[20] Liu Y, Wang T T, Zhang R , et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice[J]. J Exp Med, 2016,213(11):2473-2488.
[21] Fry J L, Al Sayah L, Weisbrod R M , et al. Vascular smooth muscle sirtuin-1 protects against diet-induced aortic stiffness[J]. Hypertension, 2016,68(3):775-784.
[22] Das A, Huang G X, Bonkowski M S , et al. Impairment of an endothelial NAD$^+$-H$_2$S signaling network is a reversible cause of vascular aging[J]. Cell, 2018,173(1):74-89.
[23] Cardus A, Uryga A K, Walters G , et al. SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence[J]. Cardiovasc Res, 2013,97(3):571-579.
[24] Dikalova A E, Itani H A, Nazarewicz R R , et al. Sirt3 impairment and SOD2 hyperacetylation in vascular oxidative stress and hypertension[J]. Circ Res, 2017.
[25] Mullican S E, Gaddis C A, Alenghat T , et al. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation[J]. Genes Dev, 2011,25(23):2480-2488.
[26] Ashburner B P, Westerheide S D, Baldwin A S, Jr . The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression[J]. Mol Cell Biol, 2001,21(20):7065-7077.
[27] Xu Y . Transcriptional regulation of endothelial dysfunction in atherosclerosis: an epigenetic perspective[J]. J Biomed Res, 2014,28(1):47-52.
[28] Anderson K M, Anderson D M, McAnally J R, et al. Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development[J]. Nature, 2016,539(7629):433-436.
[29] Wu C L, Wang Y, Jin B , et al. Senescence-associated long non-coding RNA (SALNR) delays oncogene-induced senescence through NF90 regulation[J]. J Biol Chem, 2015,290(50):30175-30192.
[30] Menghini R, Casagrande V, Cardellini M , et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1[J]. Circulation, 2009,120(15):1524-1532.
[31] Cordes K R, Sheehy N T, White M P , et al. MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity[J]. Nature, 2009,460(7256):705-710.
[32] Wu X Y, Fan W D, Fang R , et al. Regulation of microRNA-155 in endothelial inflammation by targeting nuclear factor (NF)-kappaB P65[J]. J Cell Biochem, 2014,115(11):1928-1936.
[33] Tian H, Liu C, Zou X , et al. MiRNA-194 regulates palmitic acid-induced toll-like receptor 4 inflammatory responses in THP-1 cells[J]. Nutrients, 2015,7(5):3483-3496.
[34] Goettsch C, Rauner M, Pacyna N , et al. MiR-125b regulates calcification of vascular smooth muscle cells[J]. Am J Pathol, 2011,179(4):1594-1600.
[35] Magenta A, Greco S, Gaetano C , et al. Oxidative stress and microRNAs in vascular diseases[J]. Int J Mol Sci, 2013,14(9):17319-17346.
[36] Shin S S, Park S S, Hwang B , et al. MicroRNA-106a suppresses proliferation, migration, and invasion of bladder cancer cells by modulating MAPK signaling, cell cycle regulators, and Ets-1-mediated MMP-2 expression[J]. Oncol Rep, 2016,36(4):2421-2429.
[37] Boon R A, Seeger T, Heydt S , et al. MicroRNA-29 in aortic dilation: implications for aneurysm formation[J]. Circ Res, 2011,109(10):1115-1119.
[38] Di Gregoli K, Mohamad Anuar N N, Bianco R, et al. MicroRNA-181b controls atherosclerosis and aneurysms through regulation of TIMP-3 and elastin[J]. Circ Res, 2017,120(1):49-65.
[39] Greco S, Gorospe M, Martelli F . Noncoding RNA in age-related cardiovascular diseases[J]. J Mol Cell Cardiol, 2015,83:142-155.
[40] Voelter-Mahlknecht S . Epigenetic associations in relation to cardiovascular prevention and therapeutics[J]. Clin Epigenetics, 2016,8:4.
[41] Kim E N, Kim M Y, Lim J H , et al. The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system[J]. Atherosclerosis, 2018,270:123-131.
[42] Mercken E M, Mitchell S J, Martin-Montalvo A , et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[J]. Aging Cell, 2014,13(5):787-796.
[43] Minor R K, Baur J A, Gomes A P , et al. SRT1720 improves survival and healthspan of obese mice[J]. Sci Rep, 2011,1:70.
[44] Da Luz P L, Tanaka L, Brum P C , et al. Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats[J]. Atherosclerosis, 2012,224(1):136-142.
[45] Noh R M, Venkatasubramanian S, Daga S , et al. Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus[J]. Open Heart, 2017,4(2):e000647.
[46] Krueger J G, Suarez-Farinas M, Cueto I , et al. A randomized, placebo-controlled study of SRT2104, a SIRT1 activator, in patients with moderate to severe psoriasis[J]. PLoS One, 2015,10(11):e0142081.
[47] Kalani R, Judge S, Carter C , et al. Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6[J]. J Gerontol A Biol Sci Med Sci, 2006,61(3):211-217.
[48] Redman L M, Smith S R, Burton J H , et al. Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging[J]. Cell Metab, 2018,27(4):805-815.
[49] Zhang R, Chen H Z, Liu D P . The four layers of aging[J]. Cell Systems, 2015,1(3):180-186.
[50] Cheng L Q, Zhang Z Q, Chen H Z , et al. Epigenetic regulation in cell senescence[J]. J Mol Med (Berl), 2017,95(12):1257-1268.
[51] Liu J, Jia G . Methylation modifications in eukaryotic messenger RNA[J]. J Genet Genomics, 2014,41(1):21-33.
[52] Flores J V, Cordero-Espinoza L, Oeztuerk-Winder F , et al. Cytosine-5 RNA methylation regulates neural stem cell differentiation and motility[J]. Stem Cell Reports, 2017,8(1):112-124.
[53] Nawy T . Single-cell sequencing[J]. Nat Methods, 2014,11(1):18.
[54] Ku W L, Nakamura K, Gao W , et al. Single-cell chromatin immunocleavage sequencing (scChIC-seq) to profile histone modification[J]. Nat Methods, 2019,16(4):323-325.
Options
Outlines

/

〈 〉