Research of materials genome engineering is a continuously operating project with an important impact on the national economy. Protection of intellectual property is the guarantee of the project's success. Based on the motivation of interest, this paper establishes a game model to analyze variation of the revue under the patent license within and outside the contract. In view of the perspective of sustainable development, a concept of patent sharing is proposed to comply with intellectual property protection of materials genome engineering. Based on a theoretical analysis, the paper proposes a construction strategy of patent sharing mechanism of materials genome engineering with integration of government, production, university, institute, and application.