Journal of Shanghai University（Natural Science Edition） ›› 2007, Vol. 13 ›› Issue (1): 77-81 .
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ZHU Hong;HUANG Wen zhong;PU Jia qi
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Abstract: Benzimidazoles ( 3a 〖WTHZ〗c〖WTBZ 〗, 5〖STBZ〗〖WTHZ〗a 〖WTHZ〗c ) were synthesized in a one step reductive c yclization reaction of o nitroanilines ( 1〖STBZ〗, 4〖STBZ 〗) and aryl aldehydes ( 2〖STBZ〗〖WTHZ〗a 〖WTHZ〗c ). Sodium dithionite was used as a reductive reagent. Selectivity was found when more than one nitro group existed in the substrates. A mixture of ethanol and water was u sed as solvent. The reaction was accelerated by water.
Key words: cyclization, nitro compound, selective reduction , sodium dithionite, benzimidazole
ZHU Hong;HUANG Wen zhong;PU Jia qi . Synthesis of Benzimidazoles from o Nitroanilines in a One Step Reductive Cyclization Process[J]. Journal of Shanghai University（Natural Science Edition）, 2007, 13(1): 77-81 .
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https://www.journal.shu.edu.cn/EN/Y2007/V13/I1/77
