收稿日期: 2019-04-10
网络出版日期: 2019-06-24
基金资助
青岛应用基础研究资助项目(17-1-1-46-jch);山东省自然科学青年基金资助项目(ZR2016CQ31)
Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases
Received date: 2019-04-10
Online published: 2019-06-24
鉴于成年心脏中心肌细胞的再生能力有限,使得功能性心肌细胞的丧失成为心肌重塑相关的心血管疾病的主要原因.细胞凋亡、自噬和坏死过程涉及多个复杂的信号通路,控制着心肌细胞死亡和细胞存活的平衡, 导致心肌细胞的损失. 近年发现,非编码RNA(non-coding RNAs,ncRNAs)在心血管疾病相关的细胞死亡中发挥至关重要的作用. 此外,线粒体的动态平衡与3种类型的细胞死亡密切相关,非编码RNA能够通过靶向细胞死亡信号通路中的基因来调节心肌细胞中的线粒体分裂/融合平衡. 重点介绍了在应激状态下的心肌细胞中,关于细胞凋亡/自噬/坏死和ncRNAs之间复杂关系的最新研究进展,以及对心脏病治疗的潜在应用价值.
董妍涵, 王昆 . 非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用[J]. 上海大学学报(自然科学版), 2019 , 25(3) : 389 -398 . DOI: 10.12066/j.issn.1007-2861.2137
Loss of functional cardiomyocytes is a major contributing factor to myocardial remodeling and heart diseases due to limited regenerative capacity of adult myocardium. Apoptosis, programmed necrosis, and autophagy contribute to loss of cardiac myocytes that control the balance of cardiac cell death and cell survival through multiple intricate signaling pathways. In recent years, non-coding RNAs (ncRNAs) have received much attention because of their roles in cell death of cardiovascular diseases, such as myocardial infarction, cardiac hypertrophy, and heart failure. In addition, based on the view that mitochondrial morphology is linked to three types of cell death, ncRNAs are able to regulate mitochondrial fission/fusion of cardiomyocytes by targeting genes involved in cell death pathways. This paper focuses on recent progress regarding the complex relationship between apoptosis/necrosis/autophagy and ncRNAs in the context of myocardial cell death in response to stress. This paper also provides insight into the treatment for heart diseases that will guide novel therapies in the future.
Key words： cardiomyocyte death; heart diseases; apoptosis; non-coding RNAs
| [1] | Konstantinidis K, Whelan R S, Kitsis R N . Mechanisms of cell death in heart disease[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012,32(7):1552-1562. |
| [2] | Wang K, Zhou L Y, Wang J X , et al. E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1[J]. Nature Communications, 2015,6:7619. |
| [3] | Boon R A, Dimmeler S . MicroRNAs in myocardial infarction[J]. Nature Reviews Cardiology, 2015,12(3):135-142. |
| [4] | Chekulaeva M, Filipowicz W . Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells[J]. Current Opinion in Cell Biology, 2009,21(3):452-460. |
| [5] | Filipowicz W, Bhattacharyya S N, Sonenberg N . Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?[J]. Nature Reviews Genetics, 2008,9(2):102-114. |
| [6] | Berezikov E . Evolution of microRNA diversity and regulation in animals[J]. Nature Reviews Genetics, 2011,12(12):846-860. |
| [7] | Graves P, Zeng Y . Biogenesis of mammalian microRNAs: a global view[J]. Genomics Proteomics Bioinformatics, 2012,10(5):239-245. |
| [8] | Kroemer G, Galluzzi L, Vandenabeele P , et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009[J]. Cell Death Differ, 2009,16(1):3-11. |
| [9] | Bergsbaken T, Fink S L, Cookson B T . Pyroptosis: host cell death and inflammation[J]. Nature Reviews Microbiology, 2009,7(2):99-109. |
| [10] | Orogo A M, Gustafsson A B . Cell death in the myocardium: my heart won't go on[J]. IUBMB Life, 2013,65(8):651-656. |
| [11] | Clerk A, Cullingford T E, Fuller S J , et al. Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses[J]. Journal of Cellular Physiology, 2007,212(2):311-322. |
| [12] | Xu C, Lu Y, Pan Z , et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes[J]. Journal of Cell Science, 2007,120(Pt17):3045-3052. |
| [13] | Matkovich S J, Wang W, Tu Y , et al. MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts[J]. Circulation Research, 2010,106(1):166-175. |
| [14] | Bostjancic E, Zidar N, Glavac D . MicroRNA microarray expression profiling in human myocardial infarction[J]. Disease Markers, 2009,27(6):255-268. |
| [15] | Yang B, Lin H, Xiao J , et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2[J]. Nat Med, 2007,13(4):486-491. |
| [16] | Tang Y, Zheng J, Sun Y , et al. MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2[J]. International Heart Journal, 2009,50(3):377-387. |
| [17] | Wang H, Li J, Chi H , et al. MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells[J]. Journal of Cellular and Molecular Medicine, 2015,19(9):2084-2097. |
| [18] | Rane S, He M, Sayed D , et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes[J]. Circulation Research, 2009,104(7):879-886. |
| [19] | Cheng Y, Liu X, Zhang S , et al. MicroRNA-21 protects against the H$_2$O$_2$-induced injury on cardiac myocytes via its target gene PDCD4[J]. J Mol Cell Cardiol, 2009,47(1):5-14. |
| [20] | Ren X P, Wu J, Wang X , et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20[J]. Circulation, 2009,119(17):2357-2366. |
| [21] | Li J, Donath S, Li Y , et al. MiR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway[J]. PLoS Genetics, 2010,6(1):e1000795. |
| [22] | Wang J X, Gao J, Ding S L , et al. Oxidative modification of miR-184 enables it to target Bcl-xL and Bcl-w[J]. Mol Cell, 2015,59(1):50-61. |
| [23] | Cassidy-Stone A, Chipuk J E, Ingerman E , et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization[J]. Developmental Cell, 2008,14(2):193-204. |
| [24] | Li P . MicroRNAs in cardiac apoptosis[J]. Journal of Cardiovascular Translational Research, 2010,3(3):219-224. |
| [25] | Li J, Zhou J, Li Y , et al. Mitochondrial fission controls DNA fragmentation by regulating endonuclease G[J]. Free Radical Biology& Medicine, 2010,49(4):622-631. |
| [26] | Li J, Li Y, Jiao J , et al. Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis[J]. Molecular and Cellular Biology, 2014,34(10):1788-1799. |
| [27] | Frank S, Gaume B, Bergmann-Leitner E S, et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis[J]. Developmental Cell, 2001,1(4):515-525. |
| [28] | Ong S B, Subrayan S, Lim S Y , et al. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury[J]. Circulation, 2010,121(18):2012-2022. |
| [29] | Wang J X, Jiao J Q, Li Q , et al. MiR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1[J]. Nat Med, 2011,17(1):71-78. |
| [30] | Dagda R K, Cherra S J, 3rd, Kulich S M, et al. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission[J]. The Journal of Biological Chemistry, 2009,284(20):13843-13855. |
| [31] | Wang K, Liu C Y, Zhang X J , et al. MiR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury[J]. Cell Death Differ, 2015,22(6):1058-1068. |
| [32] | Papait R, Kunderfranco P, Stirparo G G , et al. Long noncoding RNA: a new player of heart failure?[J]. Journal of Cardiovascular Translational Research, 2013,6(6):876-883. |
| [33] | Wang K C, Chang H Y . Molecular mechanisms of long noncoding RNAs[J]. Molecular Cell, 2011,43(6):904-914. |
| [34] | Piccoli M T, Gupta S K, Thum T . Noncoding RNAs as regulators of cardiomyocyte proliferation and death[J]. J Mol Cell Cardiol, 2015,89(PtA):59-67. |
| [35] | Kanduri C . Kcnq1ot1: a chromatin regulatory RNA[J]. Seminars in Cell& Developmental Biology, 2011,22(4):343-350. |
| [36] | Ishii N, Ozaki K, Sato H , et al. Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction[J]. Journal of Human Genetics, 2006,51(12):1087-1099. |
| [37] | Grote P, Wittler L, Hendrix D , et al. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse[J]. Developmental Cell, 2013,24(2):206-214. |
| [38] | Wang K, Long B, Zhou L Y , et al. CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation[J]. Nat Commun, 2014,5:3596. |
| [39] | Hsu M T, Coca-Prados M . Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells[J]. Nature, 1979,280(5720):339-340. |
| [40] | Hansen T B, Jensen T I, Clausen B H , et al. Natural RNA circles function as efficient microRNA sponges[J]. Nature, 2013,495(7441):384-388. |
| [41] | Wang K, Long B, Liu F , et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223[J]. Eur Heart J, 2016,37(33):2602-2611. |
| [42] | Koseki T, Inohara N, Chen S , et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998,95(9):5156-5160. |
| [43] | Li Y Z, Lu D Y, Tan W Q , et al. P53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC[J]. Molecular and Cellular Biology, 2008,28(2):564-574. |
| [44] | He C, Klionsky D J . Regulation mechanisms and signaling pathways of autophagy[J]. Annual Review of Genetics, 2009,43:67-93. |
| [45] | Taneike M, Yamaguchi O, Nakai A , et al. Inhibition of autophagy in the heart induces age-related cardiomyopathy[J]. Autophagy, 2010,6(5):600-606. |
| [46] | Long B, Ding S L, Liu F , et al. Autophagic program is regulated by miR-325[J]. Cell Death Differ, 2014,21(6):967-977. |
| [47] | Pan W, Zhong Y, Cheng C , et al. MiR-30-regulated autophagy mediates angiotensin Ⅱ-induced myocardial hypertrophy[J]. PLoS One, 2013,8(1):e53950. |
| [48] | Sciarretta S, Volpe M, Sadoshima J . Mammalian target of rapamycin signaling in cardiac physiology and disease[J]. Circulation Research, 2014,114(3):549-564. |
| [49] | Su M, Wang J, Wang C , et al. MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis[J]. Cell Death Differ, 2015,22(6):986-999. |
| [50] | Li Q, Xie J, Li R , et al. Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction[J]. Journal of Cellular & Molecular Medicine, 2014,18(5):919-928. |
| [51] | Song L, Su M, Wang S , et al. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1[J]. Journal of Cellular and Molecular Medicine, 2014,18(11):2266-2274. |
| [52] | Gupta S K, Foinquinos A, Thum S , et al. Preclinical development of a microRNA-based therapy for elderly patients with myocardial infarction[J]. Journal of the American College of Cardiology, 2016,68(14):1557-1571. |
| [53] | Wang K, Liu C Y, Zhou L Y , et al. APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J]. Nature Communications, 2015,6:6779. |
| [54] | Wu W, Liu P, Li J . Necroptosis: an emerging form of programmed cell death[J]. Critical Reviews in Oncology/Hematology, 2012,82(3):249-258. |
| [55] | Galluzzi L, Kepp O, Kroemer G . RIP kinases initiate programmed necrosis[J]. Journal of Molecular Cell Biology, 2009,1(1):8-10. |
| [56] | Whelan R S, Kaplinskiy V, Kitsis R N . Cell death in the pathogenesis of heart disease: mechanisms and significance[J]. Annual Review of Physiology, 2010,72:19-44. |
| [57] | Baines C P, Kaiser R A, Purcell N H , et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death[J]. Nature, 2005,434(7033):658-662. |
| [58] | Nakagawa T, Shimizu S, Watanabe T , et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death[J]. Nature, 2005,434(7033):652-658. |
| [59] | Wang K, An T, Zhou L Y , et al. E2F1-regulated miR-30b suppresses cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death[J]. Cell Death Differ, 2015,22(5):743-754. |
| [60] | Liu J, Van Mil A, Vrijsen K , et al. MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1[J]. Journal of Cellular and Molecular Medicine, 2011,15(7):1474-1482. |
| [61] | Lee E W, Kim J H, Ahn Y H , et al. Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis[J]. Nature Communications, 2012,3:978. |
| [62] | Wang J X, Zhang X J, Li Q , et al. MicroRNA-103/107 regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD[J]. Circulation Research, 2015,117(4):352-363. |
| [63] | Wang K, Liu F, Liu C Y , et al. The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873[J]. Cell Death Differ, 2016,23(8):1394-1405. |
| [64] | Nishida K, Yamaguchi O, Otsu K . Crosstalk between autophagy and apoptosis in heart disease[J]. Circulation Research, 2008,103(4):343-351. |
| [65] | Yamaguchi O, Higuchi Y, Hirotani S , et al. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling[J]. Proceedings of the National Academy of Sciences of the United States of America, 2003,100(26):15883-15888. |
| [66] | Scherz-Shouval R, Shvets E, Fass E , et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4[J]. The EMBO Journal, 2007,26(7):1749-1760. |
| [67] | Marquez R T, Xu L . Bcl-2: Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch[J]. American Journal of Cancer Research, 2012,2(2):214-221. |
| [68] | Crighton D, Wilkinson S, O'Prey J, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis[J]. Cell, 2006,126(1):121-134. |
| [69] | Diwan A, Matkovich S J, Yuan Q , et al. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death[J]. The Journal of Clinical Investigation, 2009,119(1):203-212. |
| [70] | Whelan R S, Konstantinidis K, Wei A C , et al. Bax regulates primary necrosis through mitochondrial dynamics[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012,109(17):6566-6571. |
| [71] | Li X, Zeng Z, Li Q , et al. Inhibition of microRNA-497 ameliorates anoxia/reoxygenation injury in cardiomyocytes by suppressing cell apoptosis and enhancing autophagy[J]. Oncotarget, 2015,6(22):18829-18844. |
| [72] | Ham O, Lee S Y, Lee C Y , et al. Let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3[J]. Stem Cell Research & Therapy, 2015,6:147. |
| [73] | Ng F, Tang B L . Sirtuins' modulation of autophagy[J]. Journal of Cellular Physiology, 2013,228(12):2262-2270. |
| [74] | Widera C, Gupta S K, Lorenzen J M , et al. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome[J]. J Mol Cell Cardiol, 2011,51(5):872-875. |
/
| 〈 |
|
〉 |
