收稿日期: 2019-04-10
网络出版日期: 2019-06-24
基金资助
国家自然科学基金资助项目(91839104);国家自然科学基金资助项目(81770444);中央高校基本科研业务费专项资金资助项目(2018XZZX001-10)
Role and mechanism of post-translational SUMOylation in atherosclerosis
Received date: 2019-04-10
Online published: 2019-06-24
祝昀辉, 周晓菲, 余路阳 . 蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制[J]. 上海大学学报(自然科学版), 2019 , 25(3) : 406 -414 . DOI: 10.12066/j.issn.1007-2861.2136
Atherosclerosis is a complex chronic inflammatory disease involving multiple key pathological steps such as endothelial activation, endothelial dysfunction, and local inflammatory response. SUMOylation is a newly discovered post-translational modification in eukaryotic cells and is involved in a variety of cellular biological events such as cell proliferation and differentiation, apoptosis and cell signaling. Recent studies have found that SUMOylation is closely related to the development of atherosclerosis. This paper reviews the research status of the post-translational SUMOylation involved in the process of atherosclerosis and its mechanism.
Key words： SUMOylation; atherosclerosis; immunity response
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