收稿日期: 2016-12-26
网络出版日期: 2017-04-30
基金资助
国家自然科学基金资助项目(81571833, 81271734, 81000688); 黑龙江省自然科学基金资助项目(H2015006)
Advancement of photosensitizers for photodynamic therapy
Received date: 2016-12-26
Online published: 2017-04-30
韩晓博, 郑英虹, 杨力明 . 光敏剂在光动力治疗中的研究进展[J]. 上海大学学报(自然科学版), 2017 , 23(2) : 169 -178 . DOI: 10.3969/j.issn.1007-2861.2017.01.007
This paper reviews the main types of photosensitizers in photodynamic therapy(PDT). PDT has been widely used in the treatment of tumors and non neoplastic diseases since its invention. In a photochemical reaction, a material is called photosensitizer if it can be activated by light with energy transferred to reactants without reaction. Photosensitizer is an important impact factor in PDT, and its research progress is important in the development of PDT. Photosensitizer has three generations: the first dominated by hematoporphyrin derivative, the second represented by porphyrin and porphin, and the third being modification of the second generation chemical groups. After decades of development, chemical properties of photosensitizer has become stable with less side effects.
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