Cardiac remodeling and regeneration: the spotlight in cardiovascular research
心力衰竭是多种心脏疾病的终末期状态, 严重危害人类健康. 据美国疾病预防和控制中心统计, 全美约有540 万人患有心力衰竭, 约50% 被诊断为心力衰竭的患者会在5 年之内死亡, 目前心力衰竭是65 岁以上人群最常见的出院诊断.《中国心血管病报告2015》中的数据显示, 我国有心力衰竭患者约450 万人, 心血管病死亡原因占城乡居民总死亡原因的首位.尽管血管紧张素转化酶抑制剂、血管紧张素Ⅱ受体拮抗剂、b-受体阻滞剂等临床治疗药物对抵抗心肌细胞肥大、凋亡以及坏死具有一定的作用, LCZ696(血管紧张素受体-脑啡肽酶抑制剂)较之于传统的心衰治疗药物能够进一步降低心衰住院率和心因性死亡率. 然而, 目前仍然缺乏特异性有效治愈心力衰竭的方法, 因此探索新的防治心力衰竭的疗法具有重大意义.
肖俊杰 . 心脏重构与再生: 心血管研究热点聚焦[J]. 上海大学学报(自然科学版), 2016 , 22(3) : 261 -264 . DOI: 10.3969/j.issn.1007-2861.2016.04.020
Cardiac remodeling and regeneration: the spotlight in cardiovascular research
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