收稿日期: 2019-04-17
网络出版日期: 2019-10-15
基金资助
北京市自然科学基金资助项目(4182069);中国科学院科研装备研制资助项目(YZ201235)
Temperature-controlling surface plasmon resonance system and its application
Received date: 2019-04-17
Online published: 2019-10-15
表面等离子共振 (surface plasmon resonance, SPR) 传感技术被广泛应用于生物医学、药物筛选、临床诊断、食品安全及环境污染等领域. 在实际应用中, SPR 系统对温度敏感, 亟待开发适用于温控实验的 SPR 装置. 基于角度调制型 SPR, 设计开发温控 SPR 系统, 灵敏度达到 497.8$^{\circ}$/RIU(refractive index unit, 单位折射率), 温控范围在 18$\sim $42 ℃, 控温精度为0.1 ℃, 可用于不同浓度液晶分子 (4$^\prime$-正戊基-4-氰基联苯即 5CB) 乙醇溶液的温变过程检测. 实验结果表明, 在浓度固定情况下, 25$\sim $41 ℃ 范围内 SPR 信号与温度有良好的线性关系, 相关系数均在 0.98 以上.
王少鹏, 张洪艳, 黄怀湘 . 温控表面等离子共振系统及其应用[J]. 上海大学学报(自然科学版), 2021 , 27(3) : 594 -600 . DOI: 10.12066/j.issn.1007-2861.2180
Surface plasmon resonance (SPR) sensing technology is widely used in biomedicine, pharmaceutical screening, clinical diagnosis, food safety, environmental pollution detection, and other fields. Because of the sensitivity of SPR systems to temperature, practical applications of SPR are limited. In this study, based on angle-modulation SPR, a temperature-controlling department is designed with a sensitivity of 497.8${^\circ}$/RIU (refractive index unit) and a 0.1 ℃ accuracy temperature in the range of 18$\sim$42 ℃. This SPR technology can be successfully used in various temperature changing liquid-crystal molecule systems. Results showed that the SPR signal had a good linear relationship with the temperature in the range of 25$\sim$41 ℃, with a correlation coefficient greater than 0.98.
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