收稿日期: 2019-12-31
网络出版日期: 2019-12-31
基金资助
国家自然科学基金资助项目(11771277)
Bayesian inference of HIV transmission in MSM population in Beijing
Received date: 2019-12-31
Online published: 2019-12-31
从北京地区收集了 44 例年轻男男同性恋 (men who have sex with men, MSM) 性行为者的人类免疫缺陷病毒 (human immunodeficiency virus, HIV)-1 基因序列, 利用贝叶斯推断从中提取了一些有价值的流行病学信息, 得到了传播动力学的重要参数: 有效再生数 $R_{\rm e}$. 研究结果显示, 2006 年至 2014 年 HIV/AIDS (acquired immune deficiency syndrome) 的传播速度明显加快, 这可能与过去十多年间中国年轻人群对男男同性恋人群的接受程度越来越高有关. 结果揭示了近十多年来 HIV/AIDS 在北京 MSM 中的传播趋势. 这些信息可以为疫情预测及制定干预措施提供帮助.
程金瑾, 金鑫, 汪圳, 娄洁 . 北京 MSM 人群 HIV 传播的贝叶斯推断[J]. 上海大学学报(自然科学版), 2021 , 27(6) : 1138 -1143 . DOI: 10.12066/j.issn.1007-2861.2195
In this study, the Bayesian phylogenetic method was used to extract valuable information on epidemiological processes from 44 HIV$^{-1}$ (human immunodeficiency virus$^{-1}$) gene sequences of a young men who have sex with men (MSM) population sampled in Beijing, especially the transmission dynamic parameter, i.e., the effective reproductive number $R_{\rm e}$. These results reveal that the transmission of HIV/acquired immune deficiency syndrome (AIDS) increased rapidly during the period of 2006—2014, which may have a close relation to the growing acceptance of MSM in the past decade among young Chinese. The result reveals the HIV/AIDS transmission trend among the young MSM population over the past decade. Such information is meaningful and can help people understand and predict an epidemic, and establish intervention measures for the future.
| [1] | Wu Z, Sullivan S G, Wang Y. Evolution of China's response to HIV/AIDS[J]. Lancet, 2007, 369:679-690. |
| [2] | Qian H Z, Vermund S H, Kaslow R A. Co-infection with HIV and hepatitis C virus in former plasma/blood donors: challenge for patient care in rural China[J]. AIDS, 2006, 20:1429-1435. |
| [3] | Lu L, Jia M, Ma Y. The changing face of HIV in China[J]. Nature, 2008, 455:609-611. |
| [4] | Zhang F, Dou Z, Ma Y. Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study[J]. The Lancet Infectious Diseases, 2011, 11:516-524. |
| [5] | Ye S, Xiao Y, Jin C. Effectiveness of integrated HIV prevention interventions among Chinese men who have sex with men: evaluation of a 16-city public health program[J]. PLoS One, 2012, 7:e50873. |
| [6] | Li H M, Peng R R, Li J. HIV incidence among men who have sex with men in China: a meta-analysis of published studies[J]. PloS One, 2011, 6:e23431. |
| [7] | 苗蔚. 《2005 年中国艾滋病疫情与防治工作进展》发布[J]. 中华医学杂志, 2006, 86(8): 553. |
| [7] | Miao W. World health organization progress of AIDS epidemic and prevention in China in 2005[J]. National Medical Journal of China, 2006, 86(8): 553. |
| [8] | Li Z, Liao L, Feng Y. Trends of HIV subtypes and phylogenetic dynamics among young men who have sex with men in China, 2009—2014[J]. Scientific Reports, 2015, 5:16708. |
| [9] | 刘达临. 看中国当代性文化——中国两万例性文明调查报告 [M]. 上海: 三联书店出版社, 1992. |
| [9] | Liu D L. Chinese contemporary sexual culture—a survey of 20 000 cases of sexual civilization in China [M]. Shanghai: Sanlian Bookstore Publishing, 1992. |
| [10] | 胡珍. 中国当代大学生性现状与性教育研究 [M]. 成都: 四川科学技术出版社, 2003. |
| [10] | Hu Z. A study on the current situation of sex and sex edutcaion of contemporary colloege students in China [M]. Chengdu: Sichuan Science and Technology Publishing, 2003. |
| [11] | 胡珍, 吴银涛. 新世纪中国大学生同性恋状况的变化[J]. 中国青年研究, 2013(3): 65-69. |
| [11] | Hu Z, Wu Y T. The changes of homosexuality among Chinese college students in the new century[J]. The Study of Chinese Youth, 2013(3): 65-69. |
| [12] | Pybus O, Charleston M. The epidemic behavior of the hepatitis C virus[J]. Science, 2001, 292:2323-2325. |
| [13] | Pomeroy L, Bjornstad O, Holmes E. The evolutionary and epidemiological dynamics of the paramyxoviridae[J]. J Mol Evol, 2008, 66:98-106. |
| [14] | Metropolis N, Rosenbluth A, Rosenbluth M. Equations of state calculations by fast computing machines[J]. Journal of Chemistry and Physics, 1953, 21:1087-1092. |
| [15] | Hastings W. Monte Carlo sampling methods using Markov chains and their applications[J]. Biometrika, 1970, 57:97-109. |
| [16] | Felsenstein J. Inferring phylogenies[M]. Sunderland, MA: Sinauer Associates, 2004. |
| [17] | Felsenstein J. Evolutionary trees from DNA sequences: a maximum likelihood approach[J]. J Mol Evol, 1981, 17(6): 368-376. |
| [18] | Stadlera T, Kjhnertb D, Bonhoeffera S, et al. Birth death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV)[J]. PNAS, 2013, 110:228-233. |
| [19] | Drummond A J, Ho S Y, Phillips M J. Relaxed phylogenetics and dating with confi-dence[J]. PLoS Biology, 2006, 4(5): 88. |
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