无标记生物检测中微悬臂层合梁的纳米热机变形

上海大学学报(自然科学版)

无标记生物检测中微悬臂层合梁的纳米热机变形

邢晶晶1，张能辉1，2，郑晋3

1．上海大学上海市应用数学和力学研究所，上海 200072；
2．上海大学理学院，上海 200444；
3．上海大学机电工程与自动化学院，上海 200072

收稿日期:2005-08-31 修回日期:1900-01-01 出版日期:2006-06-30 发布日期:2006-06-30
通讯作者: 张能辉1，2

Nano-Thermomechanical Deformation of a Microcantilever Laminated Beam in Label-Free Biodetection

XING Jing-jing1,ZHANG Neng-hui1，2,ZHENG Jin-3

1. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;
2. School of Sciences, Shanghai University, Shanghai 200444, China;
3. School of Mechatronial Engineering and Automation, Shanghai University, Shanghai 200072, China

Received:2005-08-31 Revised:1900-01-01 Online:2006-06-30 Published:2006-06-30
Contact: ZHANG Neng-hui1，2

摘要/Abstract

摘要：

以无标记生物检测引起的探针挠度为未知量，放弃单向受力假设，建立了在杂交表面应力和热载荷作用下生物探针纳米力学行为的连续介质力学层合梁模型.分别采用线性和均匀温度场模拟了生物探针在生物化学反应中的瞬态和稳态温度分布，从而解释了Fritz有关DNA分子杂交实验中的双金属效应.

关键词: 纳米热机变形, 微悬臂层合梁, 无标记生物检测, 杂交表面应力

Abstract:

Abandoning the uniaxial stress assumption, a continuum laminated beam model in terms of deflection induced by labelfree biodetections is set up to study nanomechanical behaviors of a biodetector subjected to hybridization surface stresses and thermal loads. Linear and uniform temperature fields are used separately to simulate transient and steady temperature distributions in biochemical reactions in order to explain the bimetallic effects in Fritz's experiments on DNA hybridizations.

Key words: hybridization surface stress, microcantilever laminated beam

, nano-thermomechanical deformation,

label-free biodetection

邢晶晶;张能辉;郑晋. 无标记生物检测中微悬臂层合梁的纳米热机变形[J]. 上海大学学报(自然科学版).

XING Jing-jing;ZHANG Neng-hui;ZHENG Jin-. Nano-Thermomechanical Deformation of a Microcantilever Laminated Beam in Label-Free Biodetection[J]. Journal of Shanghai University（Natural Science Edition）.