黄芪抗氧化部位及其与三七总皂甙配伍组分对动脉粥样硬化的改善

上海大学学报(自然科学版) ›› 2010, Vol. 16 ›› Issue (3): 327-330.

• 生命科学 • 上一篇

黄芪抗氧化部位及其与三七总皂甙配伍组分对动脉粥样硬化的改善

徐姜波，王拓，翁新楚

（上海大学生命科学学院，上海 200444）

收稿日期:2009-01-03 出版日期:2010-06-28 发布日期:2010-06-28
通讯作者: 翁新楚(1962~),男，教授，博士生导师，研究方向为脂类化学. Email:wxch@staff.shu.edu.cn
作者简介:翁新楚(1962~),男，教授，博士生导师，研究方向为脂类化学. Email:wxch@staff.shu.edu.cn

Effects of Antioxidant Part of Astragali Radix and Its Combination with Panax notoginseng saponins on Atherosclerosis

XU Jiang-bo,WANG Tuo,WENG Xin-chu

(School of Life Sciences, Shanghai University, Shanghai 200444, China)

Received:2009-01-03 Online:2010-06-28 Published:2010-06-28

摘要/Abstract

摘要：

用油脂稳定性指数(oil stability index,OSI)法筛选确定了黄芪乙酸乙酯抗氧化活性部位，并以高酯饲料喂养鹌鹑造动脉粥样硬化（atherosclerosis,AS）模型，考察黄芪抗氧化活性组分及其与三七总皂甙(PNS)配伍组分对实验性动脉粥样硬化的影响.给药8周，检测血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总抗氧化能力(T-AOC)、超氧化物歧化酶（SOD）、丙二醛（MDA）含量.结果表明，黄芪抗氧化活性组分及其与PNS的配伍组分可显著降低（P<0.1）血清TC，TG，LDL-C，TC/HDL-C系数和MDA,升高血清HDL-C及T-AOC，SOD水平，对高脂胆固醇鹌鹑动脉粥样硬化具有很好的改善作用.

关键词: 鹌鹑；动脉粥样硬化；黄芪；油脂稳定性指数(oil stability index,OSI)法；抗氧化

Abstract:

Antioxidant part of Astragali Radix was determined with an oil stability index (OSI) method. An experimental atherosclerosis in quails was established to observe the effects of the antioxidant part of Astragali Radix and its combination with Panax notoginseng saponins (PNS). After 8 weeks of feeding with the antioxidant part of Astragali Radix and its combination with PNS, the total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and malondialdehyde (MDA) in serum were measured. The results show that, compared with atherosclerosis (AS) model quails, the serum TG, TC, LDL-C, MDA are obviously lower (P＜0.1) while T-AOC, SOD are totally opposite, indicating that the antioxidant part of Astragali

Radix and its combination with PNS have good effects in antiAS.

Key words: quail; atherosclerosis (AS); Astragali Radix; oil stability index (OSI); antioxidant

徐姜波，王拓，翁新楚. 黄芪抗氧化部位及其与三七总皂甙配伍组分对动脉粥样硬化的改善[J]. 上海大学学报(自然科学版), 2010, 16(3): 327-330.

XU Jiang-bo,WANG Tuo,WENG Xin-chu. Effects of Antioxidant Part of Astragali Radix and Its Combination with Panax notoginseng saponins on Atherosclerosis[J]. Journal of Shanghai University（Natural Science Edition）, 2010, 16(3): 327-330.

黄芪抗氧化部位及其与三七总皂甙配伍组分对动脉粥样硬化的改善

Effects of Antioxidant Part of Astragali Radix and Its Combination with Panax notoginseng saponins on Atherosclerosis

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