血脑屏障和中枢神经系统疾病相关性的研究进展

doi:10.12066/j.issn.1007-2861.2315

上海大学学报(自然科学版) ›› 2022, Vol. 28 ›› Issue (6): 1063-1068.doi: 10.12066/j.issn.1007-2861.2315

• 研究论文 • 上一篇

血脑屏障和中枢神经系统疾病相关性的研究进展

宋岭, 赵琳琳, 郭思琦, 李慧灵, 张惊宇()

哈尔滨医科大学附属第四医院神经内科, 黑龙江哈尔滨 150001

收稿日期:2021-04-02 出版日期:2022-12-30 发布日期:2023-01-31
通讯作者: 张惊宇 E-mail:zhangjingyuyx@163.com
作者简介:张惊宇(1979-), 女, 教授, 博士, 研究方向为脑血管病的诊断与治疗. E-mail: zhangjingyuyx@163.com
基金资助:
外泌体对脑缺血再灌注损伤的作用及机制研究(2020-12)

Research progress on the relationship between blood brain barrier and central nervous system diseases

SONG Ling, ZHAO Linlin, GUO Siqi, LI Huiling, ZHANG Jingyu()

Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China

Received:2021-04-02 Online:2022-12-30 Published:2023-01-31
Contact: ZHANG Jingyu E-mail:zhangjingyuyx@163.com

摘要/Abstract

摘要：

中枢神经系统接受全身各处的传入信息, 经中枢神经系统整合加工后成为协调的运动传出, 或者储存在中枢神经系统内成为学习、记忆的神经基础. 中枢神经系统易受到致病因素影响而发生以精神活动障碍为主要表现的疾病, 同时亦可出现中枢神经系统退行性病变. 而血脑屏障能够使脑组织少受甚至不受循环血液中有害物质的损害, 从而保持脑组织内环境的基本稳定, 对维持中枢神经系统正常生理状态具有重要的生物学意义. 对血脑屏障与中枢神经系统疾病相关性的研究进展进行总结与综述, 以期为中枢神经系统疾病的预防与治疗提供更新与更全面的理论基础.

关键词: 中枢神经系统疾病, 血脑屏障, 脑组织

Abstract:

The central nervous system receives the input information from all parts of the body, and becomes a coordinated motor outflow after the integration and processing of the central nervous system, or stored in the central nervous system to become the neural basis of learning and memory. Central nervous system is easy to be affected by pathogenic factors, and the main manifestation is mental disorders. At the same time, central nervous system degeneration can also occur. The blood-brain barrier can make the brain tissue less or even not damaged by harmful substances in the circulating blood, thus maintaining the basic stability of the brain tissue, which has important biological significance for maintaining the normal physiological state of the central nervous system. This paper summarizes and reviews the research progress of the relationship between blood-brain barrier and central nervous system diseases, in order to provide a new and more comprehensive theoretical basis for the prevention and treatment of central nervous system diseases.

Key words: central nervous system (CNS) diseases, blood brain barrier, brain tissue

中图分类号:

R741

宋岭, 赵琳琳, 郭思琦, 李慧灵, 张惊宇. 血脑屏障和中枢神经系统疾病相关性的研究进展[J]. 上海大学学报(自然科学版), 2022, 28(6): 1063-1068.

SONG Ling, ZHAO Linlin, GUO Siqi, LI Huiling, ZHANG Jingyu. Research progress on the relationship between blood brain barrier and central nervous system diseases[J]. Journal of Shanghai University（Natural Science Edition）, 2022, 28(6): 1063-1068.

参考文献 25

[1]	Aldrich C C. Central nervous system-related pathogens[J]. Acs Infectious Diseases, 2019, 5(12): 1975.
[2]	Daneman R, Prat A. The blood-brain barrier[J]. Cold Spring Harb Perspect Biol, 2015, 7(1): a020412.
[3]	Li Y, Zhong W, Jiang Z, et al. New progress in the approaches for blood-brain barrier protection in acute ischemic stroke[J]. Brain Res Bull, 2019, 144: 46-57.
[4]	Pinheiro M A L, Kooij G, Mizee M R, et al. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke[J]. Biochim Biophys Acta (BBA)-Molecular Basis of Disease, 2016, 1862(3): 461-471.
[5]	钟高亮, 张晶晶. 多物种血脑屏障结构与功能研究进展[J]. 中国实验动物学报, 2020, 28(5): 702-707.
[6]	Pollak T A, Drndarski S, Stone J M, et al. The blood-brain barrier in psychosis[J]. Lancet Psychiatry, 2018, 5(1): 79-92.
[7]	Abdullahi W, Tripathi D, Ronaldson P T. Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection[J]. Am J Physiol Cell Physiol, 2018, 315(3): C343-C356.
[8]	Villain N, Dubois B. Alzheimer's disease including focal presentations[J]. Semin Neurol, 2019, 39(2): 213-226.
[9]	Zenaro E, Piacentino G, Constantin G. The blood-brain barrier in Alzheimer's disease[J]. Neurobiol Dis, 2017, 107: 41-56.
[10]	Cai Z, Qiao P F, Wan C Q, et al. Role of blood-brain barrier in Alzheimer's disease[J]. J Alzheimers Dis, 2018, 63(4): 1223-1234.
[11]	Yamazaki Y, Kanekiyo T. Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease[J]. Int J Mol Sci, 2017, 18(9): 1965.
[12]	李文倩, 吕鹤群, 彭拥军, 等. 缺血性脑卒中后血脑屏障损伤机制研究现状[J]. 中国临床药理学杂志, 2020, 36(21): 3533-3537.
[13]	Jiang X, Andjelkovic A V, Zhu L, et al. Blood-brain barrier dysfunction and recovery after ischemic stroke[J]. Prog Neurobiol, 2018, 163/164: 144-171.
[14]	Yang C J, Hawkins K E, Doré S, et al. Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke[J]. Am J Physiol Cell Physiol, 2019, 316(2): C135-C153.
[15]	Dadas A, Janigro D. Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy[J]. Neurobiol Dis, 2019, 123: 20-26.
[16]	Rempe R G, Hartz A M S, Soldner E L B, et al. Matrix metalloproteinase-mediated blood-brain barrier dysfunction in epilepsy[J]. J Neurosci, 2018, 38(18): 4301-4315.
[17]	Han H, Mann A, Ekstein D, et al. Breaking bad: the structure and function of the blood-brain barrier in epilepsy[J]. AAPS J, 2017, 19(4): 973-988.
[18]	Swissa E, Serlin Y, Vazana U, et al. Blood-brain barrier dysfunction in status epileptics: mechanisms and role in epileptogenesis[J]. Epilepsy Behav, 2019, 101: 106285.
[19]	何永跃, 陈礼刚. 胶质瘤免疫治疗与血脑屏障[J]. 国际神经病学神经外科学杂志, 2017, 44(1): 68-70.
[20]	Fan K L, Jia X H, Zhou M, et al. Ferritin nanocarrier traverses the blood brain barrier and kills glioma[J]. ACS Nano, 2018, 12(5): 4105-4115.
[21]	Van Tellingen O, Yetkin-Arik B, De Gooijer M C, et al. Overcoming the blood-brain tumor barrier for effective glioblastoma treatment[J]. Drug Resist Updat, 2015, 19: 1-12.
[22]	Lennon V A, Wingerchuk D M, Kryzer T J, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis[J]. Lancet, 2004, 364(9451): 2106-2112.
[23]	张静茹, 董慧芳, 张美妮. 视神经脊髓炎与血脑屏障[J]. 中华脑科疾病与康复杂志(电子版), 2016, 6(3): 177-180.
[24]	Liu H, Qiu K, He Q, et al. Mechanisms of blood-brain barrier disruption in herpes simplex encephalitis[J]. J Neuroimmune Pharmacol, 2019, 14(2): 157-172.
[25]	Niu J Q, Tsai H H, Hoi K K, et al. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation[J]. Nat Neurosci, 2019, 22(5): 709-718.

血脑屏障和中枢神经系统疾病相关性的研究进展

Research progress on the relationship between blood brain barrier and central nervous system diseases

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 25

相关文章 0

编辑推荐

Metrics

本文评价