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Journal of Shanghai University >

2021 , Vol. 27 >Issue 6: 1162 - 1170

DOI: https://doi.org/10.12066/j.issn.1007-2861.2207

Research Articles

In vitro evaluation of the prebiotic properties for Lactobacillus fermentum B44

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  • 1. Dairy Research Institute, Bright Dairy Co., Ltd. Shanghai 200436
    2. College of Life Sciences, Shanghai University, Shanghai 200444, China

Received date: 2019-05-21

  Online published: 2022-01-06

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Abstract

Lactobacillus fermentum B44 is a lactic acid strain isolated from Bulgarian homemade yoghurt. In vitro experiments showed that L. fermentum B44 has strong hydrophobicity (79.67%) and an electrostatic effect of low acid and high alkali; the strain could tolerate 1 mg/mL lysozyme and has a better adhesion and survival ability in oral cavities. In addition, it also has a high self-agglomeration rate (13.34%) and strong co-aggregation with Streptococcus mutans. When co-cultured with S. mutans, the formation of S. mutans biofilm was inhibited, and the inhibition rate was 63.43%. The above results showed that L. fermentum B44 could play a positive role in preventing and treating human dental caries; it is a potential oral probiotic and has a suitable application prospect in human oral health.

Key words： probiotics; Streptococcus mutans; biofilm; caries disease; co-aggregation

Cite this article

HAN Jin, WU Yanting, WAN Sibao, WU Zhengjun . In vitro evaluation of the prebiotic properties for Lactobacillus fermentum B44[J]. Journal of Shanghai University, 2021 , 27(6) : 1162 -1170 . DOI: 10.12066/j.issn.1007-2861.2207

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