上海大学学报(自然科学版) ›› 2016, Vol. 22 ›› Issue (3): 293-301.doi: 10.3969/j.issn.1007-2861.2016.03.018

• 心脏重构与再生专刊 • 上一篇    下一篇

运动诱导心脏再生: 治疗心血管疾病的新途径

贝毅桦, 肖俊杰   

  1. 上海大学生命科学学院再生与衰老实验室, 上海200444
  • 收稿日期:2016-04-20 出版日期:2016-06-30 发布日期:2016-06-30
  • 通讯作者: 肖俊杰(1983—), 男, 副教授, 博士, 研究方向为运动诱导的生理性心肌肥大. E-mail: junjiexiao@shu.edu.cn
  • 作者简介:肖俊杰(1983—), 男, 副教授, 博士, 研究方向为运动诱导的生理性心肌肥大. E-mail: junjiexiao@shu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目(81570362); 国家自然科学青年基金资助项目(81400647)

Exercise-induced cardiac regeneration: new therapeutic strategy for cardiovascular diseases

BEI Yihua, XIAO Junjie   

  1. Regeneration and Ageing Laboratory, School of Life Sciences, Shanghai University, Shanghai 200444, China
  • Received:2016-04-20 Online:2016-06-30 Published:2016-06-30

摘要:

虽然成年哺乳动物的心脏具备有限的再生能力, 但在心肌损伤后无法弥补丢失的心肌细胞. 运动诱导心脏再生, 不仅能促进心肌细胞的肥大和自我更新、抑制凋亡, 而且能影响血管内皮细胞和成纤维细胞的功能. IGF-1/PI3K/Akt信号通路、C/EBPβ/CITED4转录因子、一氧化氮是运动促进心脏再生的重要分子机制. 微小RNA 作为生物学标记物, 在运动诱导的心脏再生中的作用日益受到关注. 更重要的是, 运动诱导的心脏再生对心肌梗死、心肌缺血再灌注损伤、代谢型心肌病、衰老相关的心肌损伤具有保护效应. 基于运动诱导的心脏再生将成为治疗心血管疾病的新途径.

关键词:  干细胞,  心肌细胞 ,  运动 , 心脏再生

Abstract:

Adult mammalian heart has limited regenerative capacity, obviously insufficient to recover cardiomyocyte loss after injury. Exercise can induce cardiac regeneration, not only through promoting cardiomyocyte hypertrophy and renewal while reducing apoptosis, but also through modulating the functions of endothelial cells and fibroblasts. IGF-1/PI3K/Akt signaling, C/EBPβ/CITED4 transcription factors and nitric oxide are essential molecular mechanisms mediating exercise-induced cardiac regeneration. In addition increasing interests are focused on the roles of microRNAs, considered as important biomarkers, in exercise-induced cardiac regeneration. More importantly, exercise-induced cardiac regeneration protects against myocardial infarction, ischemia-reperfusion injury, metabolic cardiomyopathy, and aging-related myocardial injury. Exercise-induced cardiac regeneration may be a potential therapeutic strategy for cardiovascular diseases.

Key words:  cardiomyocyte ,  exercise ,  stem cell, cardiac regeneration